Overall, nurses demonstrated generally positive attitudes toward OR Black Box technology, despite limited prior exposure (88% reported no previous experience). More than half of participants agreed that the OR Black Box could improve safety culture, situational awareness, feedback on performance, debriefing processes, identification of intraoperative safety risks, transparency, and technological advancement in healthcare. Gender was significantly associated with several perceptions, with female nurses reporting more favorable views in multiple domains, while perceptions did not significantly differ by role, years of experience, or prior OR Black Box exposure. Qualitative responses revealed both optimism about quality improvement and concerns regarding surveillance, data use, litigation, and potential behavioral impacts, highlighting the need for clear communication, education, and policy safeguards to support nurse acceptance and readiness for OR Black Box adoption.